fgsea results for the TCGA colon adenocarcinoma data analyzed in Vitting-Seerup & Sandelin (2017), where gene-set enrichment was done both for differentially expressed genes ("Expression") and differentially spliced genes ("Splicing"). Only gene sets with an adjusted p-value below 0.05 are included, a subset of 197 gene sets.
Format
A tibble with 206 rows (one per gene set and source) and 5 columns:
- source
The analysis the gene set was found in: "Expression" or "Splicing".
- pathway
The gene set name.
- enrichment_score
Normalized enrichment score (NES) from fgsea.
- pval
p-value from fgsea.
- padj
Benjamini-Hochberg adjusted p-value from fgsea.
Source
Computed with fgsea::fgseaMultilevel() on MSigDB gene sets; see
inst/scripts/make-exampleEnrichment.R. Vitting-Seerup K, Sandelin A.
The Landscape of Isoform Switches in Human Cancers. Mol Cancer Res.
2017;15(9):1206-1220.